Progesterone and medroxyprogesterone acetate retard the development of amygdala kidling in male rats
IJMS-Iranian Journal of Medical Sciences. 1997; 22 (3-4): 138-141
in English
| IMEMR
| ID: emr-96076
ABSTRACT
The effect of progesterone and medroxyprogesterone acetate [MPA] on the development and expression of amygdala kindled seizures was studied in adult male rats. Rats were treated with either daily intraperitoneal progesterone[60 mg/kg] or weekly intramuscular MPA [25 mg/kg] during the development of kindling. Progesterone retarded both focal and generalization stages of kindling at the 10 min. injection-stimulation interval, while MPA only retarded the generalization stage. However, neither of the drugs had any effect on afterdischarge and stage 5 seizure duration after full kindling. These results suggest that progesterone antiepileptogenic effect results from inhibition of the development of both focal seizures and kindled seizure generalization
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Progesterone
/
Rats
/
Amygdala
/
Medroxyprogesterone
Language:
English
Journal:
Iran. J. Med. Sci.
Year:
1997
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