Effect of garlic on endogenous antioxidant enzymes and hyperlipidemia induced by cyclosporin - A in albino rats

ABSTRACT

In this work thirty adult male albino rats were used to study the effect of garlic on antioxidant enzymes and hyperlipidemia induced by cyclosporin A [CsA]. Rats were divided into three equal groups Rats of the first group [control group] were given 1 ml distilled water orally rats of second group were given [25 mg/kg] cyclosporin A intraperitoneally, rats of third group were given [25 mg/kg/daily] cyclosporin A intrapertioneally+garlic tablets 400 mg/kg/daily. At the end of experimental period [28 days] blood level of glutathion peroxidase [G.Px] superoxide dismutase [SOD] and plasma level of malonaldhyde, cholesterol, high density lipoproteins [HDL], low density lipoproteins [LDL] and triglycerides [TG] were determined. The study showed that cyclosporin A produce significant decrease G.Px, SOD, and malonaldhyde and significant increase plasma cholesterol, triglycerides LDL but insignificant changes in HDL as compared to control group. Also the study showed that garlic administration leads to significant increase G.Px, SOD and significant decrease plasma cholesterol, triglycerides, LDL but insignificant changes in plasma malonaldhyde as compared to group treated by cyclosporin A