Light and ultrastructural microscopic changes of liver in rats following cadmium chloride administration

ABSTRACT

Cadmium chloride [CdC1[2]] is an environmental risk factor having various toxic effects both in animals and humans. Occupational and environmental cdcl[2] exposure can result in nephrotoxicity, hepatotoxicity and skeletal damage and several types of cancer, The objective of this study was to determine the changes of Cadmium chloride on the liver of rats for light and ultrastructural microscopic examination. Fourty adult male rats were used in this study with average weight 250-300grarns were divided into four groups and Cadmium chloride solution was received subcutaneous injected in the interscapular region of the rat in sublethal dose [2.5 milligrams/kg of body weight, 5 days/week]. The first group was a control group. The second group injected with [dcl[2] for two weeks. The third group injected with [dcl[2]] for four weeks. The fourth group injected with [cdcl[2] for six weeks. The animals of each group were anaesthetized with inhalation of ether; the liver was excised and cut into small pieces for light and ultrastructural microscopic examination. Changes in the liver treated groups for light microscopic examination of present study showed congested and dilatation of the central vein with blood sinusoids, Hepatocytes showed multiple vaculated cytoplasm and presence of inflammatory cellular infiltration and areas of hyaline degeneration in the hepatic lobules. Changes in the liver treated groups for electron microscopic examination showed, the cytoplasm of hepatocytes contains swollen mitochondria with ill-defined-cristae, and decreased the glycogen granules, with some vacuoles. Administration of cadmium chloride produced significant toxic pathological changes in the liver of the rat