Effect of cadmium chloride on the testis of the adult albino rat

ABSTRACT

Cadmium chloride [CdCl[2]] is important heavy metal widely used in batteries, metal plating, pigments' plastics, and alloys. In addition to occupational exposures environmental Cdcl[2] exposure in humans may occur through cigarette smoking and dietary consumption. The aim of this study was to determine the effect of Cadmium chloride on the structure of the testis of the adult mal albino rat. Fourty adult male rats were used in this study with average weight 250-300grams were divided into four groups and Cadmium chloride solution was received subcutaneous injected in the interscapular region of the rat in sublethal dose [2.5 milligrams/kg of body weight, 5 days/week]. The first group was a control group. The second group injected with [CdCl[2]] for two weeks. The third group injected with [CdCl[2]] for four weeks. The fourth group injected with [CdCl[2]] for six weeks. The animals of each group were anaesthetized with inhalation of ether; the liver was excised and wt into small pieces. For light microscopic examination. Histological observations of the testis showed degeneration, necrosis, and separation of the spermatogenic cells from the basement membrane. As appeared by haematoxylin and eosin stain. There was an irregularity of the basement membrane as appeared by PAS stain and the interstitial tissue between the tubules is increased as appeared by Mallory stain. It was established that cadmium chloride was toxic for testis and caused sever structural damage