Synthesis of novel annulated and annelated heterocycles based on pyridine derivative

ABSTRACT

The formation of novel annulated and annelated heterocyles rings is an important task for heterocyclic chemists from various points of view. Furthermore, many condensed heterocyclic systems especially when linked to pyrimidine ring, play an important role as analgesic [1], antihypertensive [2], antipyretic and anti-inflammatory drugs [4], also as pesticides [5], herbicides[6] and plant growth regulator [7] In addition, the pyrido[2, 3-d]pyrimidine ring system is of biological interest due to the relationship between this ring and purine which is an essential part of DNA and RNA, the first is the molecule responsible for the storage of genetic information and the latter is prominently involved in the synthesis of enzymes. In continuation of our work[8, 9] aimed at developing new approachs for the synthesis of some new pyridopyrimidine products with expected biological activity