Efficacy of paroxitine for the management of premature ejaculation

ABSTRACT

Premature ejaculation is a common male sexual disorder and has been managed by psychosexual counseling, topical anesthetics and pharmacological treatments. We evaluated the efficacy of paroxetine, a potent and highly selective serotonin reuptake inhibitor, antidepressant in patients with premature ejaculation. This comparative study was carried out in the Department of Urology, Nishtar Hospital, Multan for 3 months. A total of 100 patients complaining of premature ejaculation were selected and randomly grouped-A and B. Patients in group-A received 20 mg paroxetine [n-50] and in group-B placebo for 3 first weeks regularly then on demand for 3 months. Pretreatment evaluation included history, physical examination, intra-vaginal ejaculation latency time and satisfaction with sexual intercourse. Efficacy of 2 treatments was assessed at 3 weeks and 3 months at study end point where patient reported impression of change was recorded. Trial was completed by 39 patients in each group [78%], Analysis revealed a difference in WELT increase in 2 groups. In group-A IVELT increased after paroxetine from 1 mm 10 sec to 4 min 17 sec at 3 weeks and 4 mm 6 sec at 3 months while in placebo group IVELT increase from 1 mm 1 sec at beginning to 1 min 15 sec at 3 weeks and 1 min 8 sec at c months [2 tail sig .000]. Regarding patient reported impression of change there was 2 category improvement in 56.4% patients in paroxetine group while 12.8% in placebo group. Paroxetine has significantly better results in terms of IVELT and intercourse satisfaction. Further studies are required to draw final conclusions on the efficacy of this drug in PE