Efficacy and complications of prostaglandin F2 a [alpha] for second trimester pregnancy termination in primigravida vs multigravida

ABSTRACT

To compare the efficacy and complications of extraamniotic instillation of Prostaglandin F2 Alpha [PGF 2alpha] [Pharmacia] via a Foley's catheter for second trimester pregnancy termination among primigravida and multigravida. It was a prospective study conducted at Department of Obstetrics and Gynecology, Bahawal Victoria Hospital, Bahawalpur. The study was done in the period from June 2008 to February 2009. One hundred pregnant women at 14-24 weeks of gestation divided into two groups viz. Group 1 Primigravida and Group 2 Multigravida. The mean age of primigravida was 23.12 years as compared to that [27.97 years] of multigravida. The mean gestational age was comparable in both groups. The mean induction expulsion interval found in primigravida was 16.90 hours and in multigravida .10.13 hours. The complications like dead fetus, pelvic infection, coagulopathy, rupture, incomplete abortion were less among multigravida as compared to primigravida. Our study concludes that Use of PGF 2alpha for second trimester pregnancy termination is cost effective and safe way among primigravida and multigravida. The complications like pelvic infection are less common among the multigravida