Correlation between hematological parameters and recurrent aphthous stomatitis

ABSTRACT

Recurrent Aphthous Stomatiitis is a painful oral mucosal lesion affecting about 20% of the world's population. On morphological basis RAS lesions can be divided into three main types including minor RAS [MiRAS], major RAS [MjRAS] and herpetiform RAS [HuRAS]. Eighty five percent of all RAS lesions are Minor in nature. Classification based on severity of the lesion includes simple aphthosis and complex aphthosis. The etiology of the lesion is unknown. Many factors contribute in the Pathogenesis of RAS like inflammatory bowel disease, food allergy, stress, hormonal and immunological disturbances. Vitamin B12, Iron and Ferritin deficiencies. Deficiency of Hematological parameters especially Folate and Vit b 12 causes Megaloblastic anemia which is more common in developing countries. Pakistan is a developing country and nutritional anemia is very common in the country. These nutritional deficiencies cause RAS. The aim of this review is therefore to determine the hematological parameters correlated with recurrent aphthous stomatitis