Caudal regression syndrome with partial agenesis of the corpus callosum and partial lobar holoprosencephaly: case report

ABSTRACT

Caudal regression syndrome is a rare fetal condition of diabetic pregnancy. Although the exact mechanism is not known, hyperglycaemia during embryogenesis seems to act as a teratogen. Independently, caudal regression syndrome [CRS], agenesis of the corpus callosum [ACC] and partial lobar holoprosencephaly [HPE] have been reported in infants of diabetic mothers. To our knowledge, a combination of all these three conditions has not been reported so far