Pakistan Journal of Pharmaceutical Sciences. 2010; 23 (2): 170-174
in English
| IMEMR
| ID: emr-98349
ABSTRACT
The present study was performed to determine the effect of intracerebroventricular [ICV] administration of W- 7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily [15 mg/kg for 8 days]. The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 [0.25, 0.5 and 1 micro mol/rat] was injected through ICV. Maximal possible effect percentage [MPE%] was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 [0.5 and 1 micro mol/rat] decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Sulfonamides
/
Calmodulin
/
Enzyme Inhibitors
/
Analgesics, Opioid
/
Injections, Intraventricular
/
Morphine
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2010
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