Study of neuroprotective effects of green tea antioxidant on spinal cord injury of rat
Journal of Iranian Anatomical Sciences. 2010; 7 (28-29): 145-152
in English, Persian
| IMEMR
| ID: emr-98878
ABSTRACT
Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury [SCI] has not yet been studied. Rats were randomly divided into three groups of 18 rats each as follows sham group [laminectomy], control group [SCI] and experimental group [EGCG]. Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment. The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group. EGCG treatment decreased secondary spinal cord injury
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Tea
/
Immunohistochemistry
/
Lipid Peroxidation
/
Catechin
/
Neuroprotective Agents
/
Antioxidants
Limits:
Animals
Language:
English
/
Persian
Journal:
J. Iran. Anat. Sci.
Year:
2010
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