possible role of IgE in the pathogenesis of minimal change nephrotic syndrome [MCD]

ABSTRACT

The concentration of IgE was measured in the serum of 39 children with Minimal Change Disease [MCD], 22 suffering from other renal diseases and 55 normal controls. Those children with MCD had significantly higher IgE levels than children with other forms of renal disease. [P < 0.05]. The high mean IgE levels in patients with MCD noted above along with the other previously reported presence of IgE in glomeruli of MCD patients suggest that IgE may play a role in the pathogenesis of this disese. The exact mechanism by which this might occur should be further investigated