Metformin alone versus metformin and clomiphene citrate in treatment of obese insulin resistant POCS women

ABSTRACT

Polycystic ovary syndrome [PCOS] is a syndrome of ovarian dysfunction. Its clinical manifestations may include menstrual irregularities, signs of androgen excess, and obesity. This study aimed to compare ovulation rate in women receiving metformin to women receiving both of Metfomin and Clomiphene citrate. Eighty women, among those attended at the infertility clinic at Beni-Sweif Hospital, were enrolled in this randomized study. They were classified into two equal [40 patients, each]. Group I received metformin [1700mg/day] alone, group II received a combination of metformin [1700mg/day] and clomiphene citrate [50mg/day, increasing doses up to 250mg/day]. The ovulation rate was 32.5% [13 patients] in group I versus 40% [16 patients] in group II and P value was 0.642. The pregnancy rate in group I was 20% [8 patients] versus 17.5% [7 patients] in group II and P-value 1.000. The use of metformin therapy alone can induce ovulation and early pregnancy in insulin resistant obese PCOS patients