Urodynamic and clinical differences in BHP patients treated two different alpha blockers

ABSTRACT

There is controversy data about the indication of invasive urodynamic tests in patients with BPH. This study aimed is to evaluate and compare the effect of Doxazosin and Tamsulosin on international prostate symptom score [IPSS] and objective urodynamic results. A total of 90 patients were enrolled in our study, the inclusion criteria included patients above 45 years of age, having no past history of prostatic surgery and with international prostate symptom score [IPSS] >/= 8. While the exclusion criteria included patients with prostate cancer, and patients with bladder or urethral pathology. Pretreatment complete urodynamic tests were done for all patients, and then repeated 3 months after treatment with an alpha blocker [Doxazosin 1, 2 and 4mg or Tamsulosin 0.4mg]. Significant improvement in subjective parameters and quality of life revealed after treatment with Doxazosin and Tamsulosin. Although there was significant improvement of Qmax with both drugs, but none of they produced significant decrease of Schafer's grade of obstruction. None of the two drugs [Doxazosin and Tamsulosin] improved cystometric capacity and compliance nor decreased detrusor pressure at different voiding points. None of the drugs produced significant decrease of pressure flow grade of obstruction. The improvement of filling as well as voiding parameters was not manifested with both drugs. There is significant improvement of international prostate symptom score [IPSS] and quality of life score [QL] after treatment with both drugs and were associated with an increased of uroflows [Qmax]