Phytochemical and some pharmacological properties of certain plants belonging to Asteraceae family

ABSTRACT

The aerial parts of three plants belonging to Family Asteraceae Inula crithmoides, Iphiona scarab and Jasonia montana were investigated. Phytochemicals isolated from Inula crithmoides were identified as isopimpinellin [I], scoparone [II], psoralene [III], kaempferol-3-O-alpha-L-rhamnopyranoside [IV], kaempferol -3, 7- di-O-alpha-L-rhamnopyranoside [V], kaempferol-3-O-beta- D-glucopyranoside-7-O-alpha-L-rhamnopyranoside [VI] and isorhamnetin-3-O-beta-D-glucopyranoside-7-O-alpha-L-rhamnopyranoside [VII]. From Iphiona scarba umbelliferone [VIII], xanthotoxol [IX], marmesin [X], alpha-amyrin [XI], stigmasterol [XII] and beta-sitosterol [XIII] were isolated. Moreover, Jasonia montana was found to contain 7-hydroxy-3, 5, 6, 3',. 4'-pentamethoxy flavone [XIV], 5, 7-dihydroxy- 3, 6, 3', 4' -tetramethoxy flavone [XV] and 5, 7-dihydroxy-3, 3', 4' -trimethoxy flavone [XVI], in addition to ferulic acid, caffeic acid, chrorogenic acid, alpha-amyrin, stigmasterol and beta-sitosterol. Inula crithmoides aqueous methanolic extract showed significant inhibitory effect on mouse lymphoma [Cell line L1210] in vitro study in concentration dependant manner starting from 12.5 up to 250 microg/ml [20 - 100% inhibition], respectively. In vivo study, the results indicated that Inula crithmoides methanolic extract had significant antioxidant effect against mycotoxin [Ochratoxin A]-induced oxidative stress in rat. Iphiona scabra and Jasonia montana ethanolic extracts showed potent acute anti-inflammatory, anticoagulant and hypotenssive activities comparing to the standard drugs [indomethacine]