In vivo anti-tumour activity of Wrightia tomentosa in Ehrlich ascites carcinoma bearing mice

ABSTRACT

Anti-tumour activity of ethanolic extracts of leaf and bark of Wrightia tomentosa [Fam Apocynaceae] in the mice transplanted with Ehrlich ascites carcinoma [EAC] were investigated. The EAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependent elevation in tumour-free survival and a highest number of survivors were observed at 200 mg/kg for leaf extract of ethanol. which was considered as an optimum dose for its neoplastic action. The Median survival time [MST] for this dose was approximately 44 days when compared with 23 days of non-drug treated controls. Statistical analysis also indicates that the leaf extract showed highly significant anti-tumour potency [p<0.00l] when compared with control