use of protein to creatinin ratio in random urine sample for prediction of proteinuria in preeclampsia

ABSTRACT

Preeclampsia occurs in approximately 17% of pregnancies, unknown etiology. The gold standard method for assessment of protein excreted in the urine to diagnose preeclampsia is a 24- h urine collection. However, this method is cumbersome and time consuming for the patient and laboratory. The aim of this study is to evaluate the use of protein to creatinin ratio in random urine sample for prediction of proteinuria in preeclampsia. This study is a cross-sectional descriptive study. This study was performed on 150 pregnant women who were hospitalized as preeclampsia in Ghaem Hospital during early 2006. At first, a random urine sample was collected for each patient to determine protein/creatinine ratio. Then, 24-h urine collection was analyzed for the measurement of proteinuria. Statistical analysis was performed with SPSS software and Pearson correlation coefficient for evaluation of the results. A total of 150 patients were entered the study. There was a significant relation between the 24-h urine protein and protein to creatinine ratio [r=0.659, P<0.001]. The use of e protein-to-creatinin ratio in random urine sample is a suitable replacement for the measurement of 24-h urine protein. This method is quick, reliable and cost effectiveness