Gamma interferon production by lymphocytes from children infected with L. chagasi
Braz. j. med. biol. res
;
24(8): 791-5, 1991. ilus, tab
Article
in English
| LILACS
| ID: lil-102065
ABSTRACT
The present study was performed to evaluate the ability of lymphocytes from 18 children living in an endemic area of visceral leishmaniasis (VL) to produce gamma-interferon. These children had no previous history of VL and were considered to be infected with Leishmania chagasi based on leishamnial seroconversion. The gamma IFN levels were determined by radioimmunoassay on supernatants of lymphocyte cultures (3 x 10**6/ml). stimulate with PHA (final dilution 110) and Leishamnia chagasi antigen (10µg/ml). The gamma-IFN production by lymphocytes from seroconverting children stimulated with PHA (178 ñ 151 U/ml) and Leishmania chagasi (47 ñ 77 U/ml) was significantly higher than that observed in visceral leishmaniasis. For clinical follow-up, these 18 seroconverting children were divided into three groups asymptomatic infection (N=4); self-healing subclinical illness (N=9), and sublinical infection progressing to VL (N=5). Gamma IFN levels inchildren with either asymptomatic or subclinical infection (65 ñ 85 U/ml were significantly higher (P < 0.003) than those observed in children progressing to VL (9 ñ 6 U/ml). The data demonstrate that there is an association between gamma IFN levels and the clinical course of Leishmania infection
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Index:
LILACS (Americas)
Main subject:
Antibodies, Protozoan
/
Lymphocytes
/
Interferon-gamma
/
Leishmaniasis, Visceral
Type of study:
Observational study
/
Risk factors
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1991
Type:
Article
/
Congress and conference
/
Project document
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