The possible role of circulating immune complexes in the deficiency of cell-mediated immunity in paracoccidioidomycosis
Braz. j. med. biol. res
;
22(2): 205-12, 1989. ilus
Article
in English
| LILACS
| ID: lil-105577
RESUMO
1. The nature and extent of immune abnormalities was studied in 28 untreated patients with a chronic moderate form of paracoccidioidomycosis (PCM). 2. The patients presented hyporeactivity to skin tests, diminished lymphocyte transformation by mitogens such as phytohamgglutinin-P and concanavalin A and by Paracoccidioides brasiliensis protein antigen. They also presented peripheral blood leukocytosis but normal absolute numbers of T-cell and T-cell subsets. 3. The patients had increased serum levels of C3d, as well as high levels of circulating immune complexes (CIC) detected by C1q-binding and protein A-binding assays. 4. There was a significant negarive correlation between lymphocyte transformation by mitogens and CIC levels which suggested that CIC may be involved in the genesis of the depressed cell-mediated immunity in PCM patients
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Index:
LILACS (Americas)
Main subject:
Paracoccidioidomycosis
/
Immunologic Deficiency Syndromes
/
Antigen-Antibody Complex
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
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