Effect of iv administered hyperosmotic sodium chloride on carrageenan-induced pleurisy in adrenalectomized and intact rats

ABSTRACT

The effect of administration of hyperosmotic NaCl (2ml, 7.8% NaCl, iv) on carregeenan induced pleurism was determined in adrenalectomized and intact rats. tThe volume of the pleural exudate was significantly reduced 4 h after induction by treatment with hyperosmotic NaCl for both adrenalectomized (0.08 - 0.16 ml) and intact (0.03 - 0.08 ml) animals compared to their untreated controls (0.56 - 0.44 ml and 0.26 - 0.15 ml, respectively). Similarly, hyperosmotic NaCl treatment significantly reduced the total number of inflammatory cells in the pleural cavity 29.60 x 10**6 cells for adrenalectomized animlas and 28.90 x 10**6 ñ 11.43 x 10**6 cells for intact animals compared to 63.67 x 10**6 cells for their untreated controls. Tretament with isotonic saline did not affect carrageenan-induced pleurisy. These data suggest that chemical mediator(s) of inflammation may be involved in the mechanism(s) of action of a hyperosmotic NaCl solution on the acute inflammatory response