Citotoxicidad inducida por veneno de serpientes peruanas sobre fibroblastos de ratón / Cytotoxity induced by Peruvian snake venom on fibroblasts of mice
Rev. biol. trop
;
40(1): 143-5, abr. 1992. tab, ilus
Article
in Spanish
| LILACS
| ID: lil-113478
RESUMEN
The cytotoxic effect of venoms from six crotalinae Peruvian snakes (Bathrops atrox; B. brazili; B. pictus; B. barnetti; Lachesis m. muta y Crotalus durissus terrificus) was studied in an in vitro system of BALB/c 3T3 fibroblasts grown in Dulbecco modified minimal essential medium at 37-C in a humidified atmosphere of 5% CO2 - 95% air. The viability of the cells was evaluated 24 hours after the treatment with the different venoms, using the method of exclusion of trypan blue. The six venoms produced cytotoxic effects at 24 hours on the 3T3 fibroblasts. The venom from B atrox was the most potent (DE50=162 ng/ml) and that from B. barnetti the least (DE50=7182ng/ml)
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Index:
LILACS (Americas)
Main subject:
Snake Venoms
/
In Vitro Techniques
Limits:
Animals
Country/Region as subject:
South America
/
Peru
Language:
Spanish
Journal:
Rev. biol. trop
Journal subject:
Biology
/
Tropical Medicine
Year:
1992
Type:
Article
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