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Anxiogenic action of acute but not repeated cocaine administration handling-habituate3d mice in the plus-maze test
Braz. j. med. biol. res ; 25(7): 713-6, 1992. tab
Article in English | LILACS | ID: lil-113562
ABSTRACT
The present study was designed to determine the putative anxiogenic effects of cocaine on the performance of mice in the elevated plus-maze test of anxiety. Male Swiss mice, weighing abouth 30 g, treated repeatedly with saline for 8 days and challenged with a single injection of cocaine 10 mg/kg, ip, 1 ml/100 g, on day 10, showed a clear reduction in the relative number (%) of entries and time spent on the open arms of the maze (30.5) ñ 4.5 and 29.4 ñ 5.0 vs 47.1 ñ 6.2 and 46.7 ñ 9.4, for the controls, respectively, N=7-8 animals). These data suggest an anxiogenic action of cocaine (10 mg/kg) for 8 days failed to alter the indices of anxiety in the test. These findings suggest that the emotional changes induced by the handling procedures for 8 days may be related to the occurrence of anxiogenic responses to cocaine by mice
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Index: LILACS (Americas) Main subject: Anti-Anxiety Agents / Cocaine / Habituation, Psychophysiologic / Ear, Inner / Motivation Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1992 Type: Article

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Index: LILACS (Americas) Main subject: Anti-Anxiety Agents / Cocaine / Habituation, Psychophysiologic / Ear, Inner / Motivation Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1992 Type: Article