Differences in macrophage stimulation and leukocyte accumulation in response to intraperitoneal administration of glucose/mannose-binding plant lectins
Braz. j. med. biol. res
;
25(8): 823-6, 1992. tab
Article
in English
| LILACS
| ID: lil-113575
ABSTRACT
Peritoneal macrophage stimulation (rapid spreading on glass surface and hydrogen peroxide production) and inflammatory reaction (leukocyte accumulation) obtained in C3H/HeJ mice at 8 weeks of age, after a single ip injection of 10 ug concanavalin A (Con A), a lectin extracted from Canavalia ensiformits, were compared with those obtained with two other glucose/mannose-binding lectins extracted from Canavalia brasiliensis (Con Br) and Dioclea grandiflora (DGL). All lectins enhaced macrophage spreading 3-to 4-fold at 24-72 compared to control. Stimulation of hydrogen peroxide release by Con A, Con Br and DGL lasted 1,2 anmd 3 days, respectively. Leukocyte cell influx at 24-72 h after lectin injection consisted mainly of mononuclear cells. Con A induced a moderate increase in the total number of peritoneal cells,. whereas administration of Con Br or DGL increased the number of peritoneal cells 2-to 3-fold. The results indicate that DGL and Con Br have more pronounced effects on macrophage stimulation and inflammatory reactions than Con A
Search on Google
Index:
LILACS (Americas)
Main subject:
Glucose
/
Infusions, Parenteral
/
Lectins
/
Leukocytes
/
Macrophage Activation
/
Mannose
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1992
Type:
Article
Similar
MEDLINE
...
LILACS
LIS