Effect of age on antinociceptive effects of elevated plus-maze exposure
Braz. j. med. biol. res
; 25(8): 827-9, 1992. tab
Article
in En
| LILACS
| ID: lil-113576
Responsible library:
BR26.1
RESUMO
It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. Furthermore, age has been reported to increase the anxiety levels in rats as measured in the elevated plus-maze. In the present investigation 10 young (3 months), 10 middle-age (14-16 months) and 10 old (28-30 months) male Wistar rats were tested by the tail withdrawal assay of nociception before (baseline) and at 0(T) and 10(T2) min after a 5-min exposure to the elevated plus-maze apparatus. Only old rats presented an increase in tail withdrawal latencies after elevated plus-maze exposure, even though this effect was statistically significant only immediately after exposure to the apparatus (baseline = 2.5 ñ 0.3 s; T1 = 3.8 ñ 0.3s; T2 = 3.3 ñ 0.4 s). The results indicate that exposure to the elevated plus-maze induces a rapidly reversed and age-dependent antinociception in rats. They are also consistent with the proposed greater sensitivity of old rats to anxiogenic effects of the plus-maze
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Index:
LILACS
Main subject:
Anxiety
/
Pain Measurement
/
Nociceptors
/
Age Factors
/
Ear, Inner
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1992
Type:
Article