Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease)
Braz. j. med. biol. res
;
25(9): 889-93, 1992. ilus
Article
in English
| LILACS
| ID: lil-113587
ABSTRACT
A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release(16,578 vs 6,242 ñ 1,136 uU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 uM FFA/106 cells at 5.0 uM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa
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Index:
LILACS (Americas)
Main subject:
Insulin Resistance
/
Adipose Tissue
/
Adiposis Dolorosa
/
Glucose
/
Hormones
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1992
Type:
Article
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