Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
Mem. Inst. Oswaldo Cruz
;
87(2): 209-15, abr.-jun. 1992. tab, ilus
Article
in English
| LILACS
| ID: lil-116307
ABSTRACT
Phenothiazines were observed to have a direct effect on Trypanosoma cruzi and on its in vitro interaction with host cells. They caused lysis of trypomastigotes (50 uM/24 h) and,to a lesser extent, epimastigote proliferation. Treatment of infected peritoneal macrophages with 12.5 uM chlorpromazine or triflupromazine inhibited the infection; this effect was found to be partially reversible if the drugs were removed after 24 h of treatment. At 60 uM, the drugs caused damage to amastigotes interiorized in heart muscle cells. However, the narrow margin of toxity between anti-trypanossomal activity and damage to host cells mitigates against in vivo investigation at the present time. Possible hypothesis for the mechanism of action of phenothiazines are discussed
Full text:
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Index:
LILACS (Americas)
Main subject:
Phenothiazines
/
Trypanosoma cruzi
/
Host-Parasite Interactions
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1992
Type:
Article
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