Effects of post-training ß-endorphin and Met-enkephalin administration on two-way active avoidance task in well-nourished and protein malnourished rats
Acta physiol. pharmacol. ther. latinoam
; 42(2): 113-21, 1992. tab
Article
in En
| LILACS
| ID: lil-116659
Responsible library:
BR1.1
RESUMO
Protein malnutrition during suckling period or throughout the life affects the hypothalamic ß-endorphinergic system of adult rats. In the present study, rats were under nourished during suckling by feeding their dams an 8% casein diet whereas well-nourished dams recived a 25% casein diet from birth until weaning (21 day of postnatal life). After weaning, the offsprings were maintained with the same diet as their dams. When rats were 3 month-old, they were subjected to two-way active avoidance task. Protein malnutrition did not affect the performance in the two-way active avoidance task. Post-training ß-endorphin or Met-enkephalin administration impaired the retention of shuttle avoidance tast in both well-nourished and undernourished rats. However, the amnesic effect of the peptides was only achieved in undernourished rats with higher doses of apioids when compared to the well-nourished rats. These data suggest that undernourished rats present alterations in opioid sensitivity which may be related to changes in the levels of ß-endorphin previously observed both in brain and hypothalamus of early undernourished adults rats
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Index:
LILACS
Main subject:
Avoidance Learning
/
Enkephalin, Methionine
/
Beta-Endorphin
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Protein-Energy Malnutrition
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Diet
Limits:
Animals
Language:
En
Journal:
Acta physiol. pharmacol. ther. latinoam
Journal subject:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Year:
1992
Type:
Article
/
Project document