An experimental and clinical assay with ketoconazole in the treatment of Chagas disease
Mem. Inst. Oswaldo Cruz
;
88(1): 149-53, jan.-mar. 1993. tab
Article
in English
| LILACS
| ID: lil-117664
RESUMO
Ketoconazole an azole antifungic drug which is already in the market has also been demonstrated to be active against Trypanossoma cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity against different T. cruzi strains naturally resistant or susceptible to both standard drugs Nifurtimox and Benznidazole used clinically in Chagas disease. Moreover, we have shown that the association of Ketoconazole plus Lovastatin (an inhibitor of sterol synthesis), which has an antiproliferative effect against T. cruzi in vitro, failed to enhance the supressive effect of Ketoconazole displayed when administered alone to infected mice. Finally, administration in chronic chagasic patients of Ketoconazole at doses used in the treatment of deep mycosis also failed to induce cure as demonstrated by parasitological and serological tests. The strategy of identify and test drugs which are already in the market and fortuitously are active against T. cruzi has been discussed
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
In Vitro Techniques
/
Chagas Disease
/
Ketoconazole
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1993
Type:
Article
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