Use of PCR for the determination of the frequency of the F508 mutation in Brasilian cistic fibrosis patients
Mem. Inst. Oswaldo Cruz
;
88(2): 309-12, abr.-jun. 1993.
Article
in English
| LILACS
| ID: lil-119495
RESUMO
The F508 mutation in the cystic fibrosis (CF) gene was studied in a population of 18 Brazilian CF patients and their 17 families by use of PCR and differential hybridization with oligonucleotides. In a total of 34 chromosomes considered, 12 (35%) carried the F508 deletion, a frequency much lower than that reported in most other populations. As a consequence, CF in Brazil would be predominantly caused by mutations different from the F508 deletion
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Index:
LILACS (Americas)
Main subject:
Genetic Engineering
/
Cystic Fibrosis
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1993
Type:
Article
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