On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine - induced fatty liver
Mem. Inst. Oswaldo Cruz
;
88(2): 313-6, abr.-jun. 1993.
Article
in English
| LILACS
| ID: lil-119496
RESUMO
In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity
Full text:
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Index:
LILACS (Americas)
Main subject:
Carbon Tetrachloride
/
Fatty Liver
/
Lipoprotein Lipase
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1993
Type:
Article
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