Genetic complementation analysis of two independently isolated hycanthone-resistant strains of Schistosoma mansoni
Mem. Inst. Oswaldo Cruz
;
87(supl.4): 211-4, 1992. tab
Article
in English
| LILACS
| ID: lil-125652
ABSTRACT
The objective of this study is to determine whether various hycanthone resistant strains of schistosomes which have been independently isolated are all affected in the same gene. A strain obtained from a Brazilian patient was compared with a strain of Puerto Rican origin selected in the laboratory. If the mutation conferring resistance involved two different genes, one would expect that the progeny of a cross between the two strains would show complementation, i.e. it would be sensitive to the drug. We have performed such a cross and obtained F1 hybrid worms wich were essentially all resistant, thus suggesting that the mutation conferring resistance in the two strains involves the same gene
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Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
Genetic Complementation Test
/
Nandrolone
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1992
Type:
Article
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