DNA alkylation by carbon-centered radicals
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;25(12): 1171-83, 1992. ilus
Article
in En
| LILACS
| ID: lil-134496
Responsible library:
BR26.1
RESUMO
1. Over the last two decades, the prevalent view in chemical carcinogenesis has been that most free radicals do not bind to DNA. Recent studies, however, are demonstrating formation of adducts between DNA and free radicals such as hydroxyl radicals and aromatic cation radicals. 2. Within this context, we discuss the recent work from our group demonstrating DNA alkylation by carbon-centered radicals formed during biotransformation of genotoxic hydrazine derivatives both in vitro and in vivo. 3. The mutagenic potential of the identified methyl radical adduct, C8-methylguanine, is discussed, and other possible biological sources of carbon-centered radicals are presented
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Index:
LILACS
Main subject:
DNA
/
Carbon
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1992
Type:
Article