Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil
Rev. Inst. Med. Trop. Säo Paulo
;
34(3): 227-32, maio-jun. 1992. tab
Article
in English
| LILACS
| ID: lil-134509
RESUMO
Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from Säo Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused
Full text:
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Index:
LILACS (Americas)
Main subject:
Urban Population
/
Blood Transfusion
/
Factor IX
/
Factor VIII
/
HIV Infections
/
HIV-1
/
Hemophilia A
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
1992
Type:
Article
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