Canatoxin induces activation on mice peritoneal macrophages
Braz. j. med. biol. res
;
25(10): 1033-5, 1992. tab, graf
Article
in English
| LILACS
| ID: lil-134648
ABSTRACT
Canatoxin (CNTX), the toxic protein from Canavalia ensiformis seeds, injected into the peritoneal cavities of mice (10 micrograms/cavity) induced a significant neutrophil migration (10.5 +/- 0.5 x 10(6) cells/cavity) after 4 h. A later migratory effect (48 h) on mononuclear cells, predominantly macrophages, was also observed (controls 7 +/- 0.9; CNTX 17 +/- 2.0 x 10(6) cells/cavity). These CNTX-elicited macrophages, when compared to resident cells (R) or cells elicited by thioglycollate (TG), had an increased content of the lysosomal enzyme N-acetyl-beta-D-glucosaminidase (R 4.5 +/- 0.5; TG 7.2 +/- 1.0; CNTX 20.2 +/- 3.0 mU/10(6) cells) and a greater (> or = 100%) phagocytic activity. The data suggest that CNTX-stimulated macrophages presented some characteristics of activated cells
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Index:
LILACS (Americas)
Main subject:
Toxins, Biological
/
Macrophages, Peritoneal
/
Lectins
/
Macrophage Activation
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1992
Type:
Article
/
Congress and conference
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