The fate of GPI-anchored molecules
Braz. j. med. biol. res
;
27(2): 289-95, Feb. 1994. ilus
Article
in English
| LILACS
| ID: lil-140266
ABSTRACT
Glycosylphosphatidylinositol (GPI)-anchored proteins comprise a diverse class of membrane molecules. They protect cells from complement-mediated lysis, control cell to cell adhesion, activate T cells, and play a role in the etiology of slow viral diseases. Despite their functional diversity, GPI-anchored proteins are all attached to the plasma membrane by a common glycolipid anchor. We will examine one aspect of GPI-anchor metabolism, namely, the processing of the molecule after it arrives at the plasma membrane. After biosynthesis and transport to the plasma membrane, the GPI-anchored protein can be endocytosed and degraded or cleaved and released. The enzymatic machinery controlling the catabolism of GPI-anchored molecules at the plasma membrane is likely to play a central role in regulating the cell surface expression of these molecules
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Index:
LILACS (Americas)
Main subject:
Phosphatidylinositols
/
Phospholipase D
/
Proteoglycans
/
Prions
/
Glycolipids
/
Heparitin Sulfate
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1994
Type:
Article
/
Congress and conference
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