Phospholipases C and the pathogenesis of Listeria
Braz. j. med. biol. res
; 27(2): 357-61, Feb. 1994. ilus
Article
in En
| LILACS
| ID: lil-140275
Responsible library:
BR26.1
RESUMO
Listeria monocytogenes is a model intracellular pathogen which escapes from a host cell vacuole, grows intracytoplasmically, and spreads cell to cell without an extracellular phase. A number of genes necessary for pathogenicity have been discovered, two of which encode phospholipases C, a PI-PLC and a broad-range PLC. Single and double mutants were constructed with in-frame deletions in one or both PLCs. Characterization of the strains indicated that the two PLCs may have overlapping functions as the double mutant was 500-fold less virulent while the single mutants had a negligible effect on virulence. The role of the PLCs appears to be multifactorial as PI-PLC has a role in escaping from the initial host vacuole and the broad-range PLC appears to have a role in cell to cell spreading
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Index:
LILACS
Main subject:
Type C Phospholipases
/
Listeria monocytogenes
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1994
Type:
Article
/
Congress and conference