Your browser doesn't support javascript.
loading
Estudios citogenéticos en niños chilenos con leucemia linfoblástica aguda / Cytogenetic studies in chilean children with acute lymphoblastic leukemia
Rev. méd. Chile ; 122(11): 1239-47, nov. 1994. tab, ilus
Article in Es | LILACS | ID: lil-144021
Responsible library: CL1.1
ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer. The leukemic cells of ALL patients show several well defined numeric and structural chromosomal abnormalities which are universally known for its prognostic implications. We studied a group of 44 children with ALL, to investigate the incidence of chromosome aberrations in ALL, its lymphocyte lineage and some clinical feature associations, ans the finding of non previously described aberrations. A high proportion of patients (79.5 per cent) showed chromosomal abnormalities. Most of them had a pseudodiploid karyotype (46 chromosomes), characterized mainly by a translocation. In relation to chromosome number, 27 percent of them were hyperdiploid with more than 50; 9 percent hyperdiploid between 47 - 50 and 7 percent hypodiploid (less than 46). Among structural aberrations found, were the following recurrent translocations t(1;19), t(4;11), t(9;22) in 6.8 percent, 9.1 percent and 2.3 percent of cases respectively, all related to an early B immunophenotype. Other translocations found, compromised regions 7q22,9p21 -24. Two new translocations in ALL were found 8(1;5)(q23;q33), apparently balanced and t(13;21)(q14;q22), unbalanced. Other recurrent structural changes found were deletion (6q), (7q), (7q), (11q), (12q), inversion (3q), isochromosome (7q), maker chromosomes and double minutes. The distribution of chromosome abnormalities in this group of patients was in agreement with previous reports from other investigators
Subject(s)
Search on Google
Index: LILACS Main subject: Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Chile Language: Es Journal: Rev. méd. Chile Journal subject: MEDICINA Year: 1994 Type: Article / Project document
Search on Google
Index: LILACS Main subject: Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Chile Language: Es Journal: Rev. méd. Chile Journal subject: MEDICINA Year: 1994 Type: Article / Project document