Adhesion to laminin is down-regulated upon retinoic acid-induced F9 cell differentiation: a role for alpha6/beta1 integrin

Elias, M. C. Q. B; Chammas, R; Giorgi, R. R; Frochtengarten, F; Santos, C. L. S; Brentani, R. R

Elias, M. C. Q. B; Chammas, R; Giorgi, R. R; Frochtengarten, F; Santos, C. L. S; Brentani, R. R.

Braz. j. med. biol. res ; 27(9): 2181-4, Sept. 1994. graf

Article in English | LILACS | ID: lil-144470

RESUMO

RESUMO

F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha6/beta1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha6/beta1 integrin on the cell surface

Subject(s)

Mice; Animals; Down-Regulation; Integrins/physiology; Laminin/physiology; Tretinoin/pharmacology; Cell Adhesion; Bucladesine/pharmacology; Cell Differentiation; Flow Cytometry; Integrins/metabolism; Laminin/metabolism; Protein Binding; Receptors, Laminin/metabolism; Receptors, Laminin/physiology; Tumor Cells, Cultured/drug effects

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Index: LILACS (Americas) Main subject: Tretinoin / Down-Regulation / Integrins / Laminin Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1994 Type: Article / Congress and conference

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