Central angiotensin converting enzyme-blockade and thirst
Braz. j. med. biol. res
;
26(9): 999-1007, Sept. 1993. graf
Article
in English
| LILACS
| ID: lil-148774
ABSTRACT
1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100 per cent ) and water deprivation (90 per cent ) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60 per cent ). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied
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Index:
LILACS (Americas)
Main subject:
Preoptic Area
/
Thirst
/
Angiotensin-Converting Enzyme Inhibitors
/
Drinking
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1993
Type:
Article
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