Capillaria hepatica: a cause of septal fibrosis of the liver
Mem. Inst. Oswaldo Cruz
;
88(3): 441-7, July-Sept. 1993. ilus
Article
in English
| LILACS
| ID: lil-148799
RESUMO
Fine, long, fibrous septa were observed as a late change developing in the acinar zone III of the liver of rats experimentally infected with the helminth Capillaria hepatica. Hepatic septal fibrosis begun 30 days after inoculation of embryonated eggs into the stomach of rats and became clearly evident from the 40th day onwards. Experimental observation was undertaken for 170 days. Septal fibrosis increased progressively with time and was most marked when the parasitic nodules formed around larvae, disintegrating worms and eggs were involving. Septal fibrosis of the liver has not been previously recognized as a manifestation of hepatic capillariasis. The presence of sequestered parasite antigens, probably being slowly released within the liver, appears to be a major factor in the pathogenesis of hepatic septal fibrosis observed in rats with C. hepatica infection
Full text:
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Index:
LILACS (Americas)
Main subject:
Capillaria
/
Liver Cirrhosis, Experimental
/
Liver Diseases, Parasitic
/
Nematode Infections
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1993
Type:
Article
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