Effect of conbined administration of counterregulatory hormones during insulin-induced hypoglycemia in rats: lipolysis mediated by a Beta-adrenergic mechanism contributes to hyperglycemia
Braz. j. med. biol. res
;
27(12): 2883-7, Dec. 1994. graf
Article
in English
| LILACS
| ID: lil-153288
ABSTRACT
The synergistic effect of combined injection of glucagon (G), cortisol (C) and phenylephrine + isoproterenol (E) during hypoglycemia in male adult Wistar rats was investigated. For this purpose we injected insulin (1 mg/kg), individually or combined (G+C, G+E, C+E and C+G+E). All drugs were injected ip and all rats were killed 60 min after insulin injection. The rise in glycemia with C+G+E was greater (delta = 107 mg/dl) than the sum of the responses to injection of C, G and E individually, or in double combination plus any single hormone injection. This synergistic effect was reproduced by G + C + isoproterenol (Iso) but not by G + C + phenylephrine (delta = 0 mg/dl). The results also showed a clear relationship between hyperglycemia and lipolysis. Thus, lipolysis mediated by a ß-adrenergic mechanism played a significant role in promoting hyperglycemia when Iso was combined with G and C
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Index:
LILACS (Americas)
Main subject:
Glucagon
/
Hydrocortisone
/
Hypoglycemia
/
Insulin
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1994
Type:
Article
/
Congress and conference
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