Prostaglandin A1, inhibits replication of Mayaro virus in Aedes albopictus cells
Braz. j. med. biol. res
; 28(1): 27-30, Jan. 1995. ilus
Article
in En
| LILACS
| ID: lil-153327
Responsible library:
BR1.1
ABSTRACT
Prostaglandin A1 (PGA1) reduced Mayaro virus replication in Aedes albopictus (mosquito) cells in culture. The highest nontoxic dose of PGA1, 7.5µM, decreased virus production by 90 percent. In Mayaro virus-=infected cells, PGA1 inhibited virus-specific protein synthesis. However, in mock-infected cells the presence of PGA, stimulated the synthesis of several proteins with molecular masses of 70, 57 and 23 kDa, respectively. The data obtained from this study show that PGA1 plays a role in the metabolic regulation of Aedes albopictus cells, blocking the synthesis of Mayaro virus and inducing the synthesis of cellular polypeptides
Search on Google
Index:
LILACS
Main subject:
Peptides
/
Prostaglandins A
/
Viral Proteins
/
Virus Replication
/
Alphavirus
/
Aedes
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1995
Type:
Article