The interation of blood proteins with alpha-alumina
Braz. j. med. biol. res
;
27(11): 2569-71, Nov. 1994.
Article
in English
| LILACS
| ID: lil-153977
RESUMO
The use of alumina (Ó-Al2O3) as a material for cardiovascular applications was investigated on the basis of protein adsorption and thrombus formation on the material. The adsorption of 125I-labelled albumin and fibrinogen from phosphate buffered saline (pH 7.35, 0.100 M NaCl, 8.66 mM KH2PO4 and 41 mM Na2HPO4) solution on ceramic discs of alumina was studied. Both albumin and fibrinogen presented affinity for ceramic surfaces, with adsorptions of 1.47 + or - 0.6 ng/cm2 and 0.198 + or - 0.01 ng/cm2, respectively. Scanning electron micrographs of the Ó-Al2O3 surfaces after contact of the discs with whole human blood showed a thrombogenic behavior of alumina alpha. These results indicate a hemoincompatible property. Although critical surface tension (YC: 21.8 dynes/cm) of the disc surfaces determined by contact angle technique of sessile drops indicates that alumina alpha is a biocompatible material, by this criterion, the data reported here indicate that Ó-Al2O3 cannot be used for cardiovascular applications
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Index:
LILACS (Americas)
Main subject:
Blood Vessel Prosthesis
/
Ceramics
/
Aluminum Oxide
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1994
Type:
Article
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