Effect of nicotine in randomized skin flaps in rats

Gomes, H. Carvalho; Bueno, P. C. S; Scardoeli, C. A. C; Landman, M. R. L; Ishizuka, M. M. A; Martins, D. M. F. S; Andrews, J. M

Gomes, H. Carvalho; Bueno, P. C. S; Scardoeli, C. A. C; Landman, M. R. L; Ishizuka, M. M. A; Martins, D. M. F. S; Andrews, J. M.

Rev. Hosp. Säo Paulo Esc. Paul. Med ; 5(3/4): 13-7, July-Dec. 1994. ilus, tab

Article in English | LILACS | ID: lil-155145

ABSTRACT

ABSTRACT

This study analyzed the perfusion of randomized skin flaps in rats after nicotine injections, in doses that could be compared with heavy and light smorkers. A skin flap was elevated after 12 weeks of nicotine adminsitration and the percentage of necrotic area was determined thereafter. There was a statistically significant difference between "heavy smokers" in the preoperative (G3) and preoperative and postoperative periods (G5), suggesting a deleterious effect of nicotine in the postoperative period

Subject(s)

Animals; Male; Rats; Nicotine/pharmacology; Surgical Flaps/pathology; Regional Blood Flow; Nicotine/administration & dosage; Nicotine/blood; Photomicrography; Postoperative Period; Rats, Wistar

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Index: LILACS (Americas) Main subject: Surgical Flaps / Nicotine Limits: Animals Language: English Journal: Rev. Hosp. Säo Paulo Esc. Paul. Med Journal subject: Medicine Year: 1994 Type: Article

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