Apoptosis as a cause of T-cell unresponsiveness in experimental Chagas' disease
Braz. j. med. biol. res
;
28(8): 913-8, Aug. 1995. ilus
Article
in English
| LILACS
| ID: lil-156287
RESUMO
A murine model of Chagas'disease induced by metacyclic forms of T. cruzi was used to evaluate T-cell function during infection. T-cell unresponsiveness to TcR; CD3 stimulation in vitro and lymphocyte activation in vivo occurred simultaneously. These paradoxical findings ar discussed in the light of recent evidence that mature activated T cells become susceptible to TcR-mediated apoptosis. Activation-induced death in T cells from T. cruzi-infected mice has recently been demonstrated in this model. Evidence that TcR-induced death of activated T cells could be a cause for T-cell unresponsiveness in vitro and in vivo, as well as the possible molecular mechanisms involved, are discussed.
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Index:
LILACS (Americas)
Main subject:
In Vitro Techniques
/
T-Lymphocytes
/
Chagas Disease
/
Apoptosis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1995
Type:
Article
/
Congress and conference
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