El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica / Major histocompatibility system as a risk factor of alcoholic hepatic disease
Rev. méd. Chile
;
123(6): 687-93, jun. 1995. tab
Article
in Spanish
| LILACS
| ID: lil-156937
ABSTRACT
Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and changes from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44 percent). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease
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Index:
LILACS (Americas)
Main subject:
Liver Cirrhosis, Alcoholic
/
Major Histocompatibility Complex
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1995
Type:
Article
/
Project document
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