Characterization of T cell clones from chagasic patients: predominance of CD8 surface phenotype in clones from patients with pathology
Mem. Inst. Oswaldo Cruz
;
90(4): 503-6, jul.-ago. 1995. tab
Article
in English
| LILACS
| ID: lil-157301
ABSTRACT
Human Chagas' disease, caused by the protozoan Trypanosoma cruzi, is associated with pathological processes whose mechanisms are not known. To address this question, T cell lines were developed from chronic chagasic patients peripheral blood mononuclear cells (PBMC) and cloned. These T cell clones (TCC) were analyzed phenotypically with monoclonal antibodies by the use of a fluorescence microscope. The surface phenotype of the TCC from the asymptomatic patient were predominantly CD4 positive (86 por cento). On the contrary, the surface phenotype CD8 was predominant in the TCC from the patients suffering from cardiomegaly with right bundle branch block (83 por cento), bradycardia with megacolon (75 por cento) and bradycardia (75 por cento). Future studies will be developed in order to identify the antigens eliciting these T cell subpopulations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
CD4-Positive T-Lymphocytes
/
Chagas Disease
/
Microscopy, Fluorescence
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1995
Type:
Article
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