Chemical sympathectomy blocks androgen biosynthesis during prepuberty
Braz. j. med. biol. res
;
28(10): 1109-12, Oct. 1995. tab
Article
in English
| LILACS
| ID: lil-161003
ABSTRACT
Twenty-one-day old male Wistar rats were injected subcutaneously with guanethidine (GUA) at doses of 5 and 10 mg kg-1 day-1 for 20 days. Animals were sacrificed by decapitation during the prepubertal (41 days of age) and early-pubertal (51 days of age) periods of sexual development. The tests were collected, frozen in liquid N2 and stored at -70oC until determination of testicular progesterone (P), androstenedione (A) and testosterone (T). Higher levels of P (2.18 +/- 0.24 ng/g, control = 1.24 +/- 0.16 ng/g) associated with decreased with decreased levels of androgens (A = 0.26 +/- 0.06 ng/g T = 2.05 +/- 0.19 ng/g; control = 1.86 +/- 0.76 ng/g and 8.48 +/- 1.16 ng/g, respectively) were observed in 10 mg GUA-treated rats of prebubertal age, while only P levels (3.12 +/- 0.51 ng/g, control = 1.73 +/- 0.27 ng/g) were incresead in rats of early pubertal...
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Index:
LILACS (Americas)
Main subject:
Sexual Maturation
/
Sympathectomy, Chemical
/
Guanethidine
/
Androgens
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1995
Type:
Article
/
Congress and conference
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