Effect of a non-peptide angiotensin receptor antagonist on water intake caused by centrally administered carbachol on the rat
Braz. j. med. biol. res
;
29(2): 245-7, Feb. 1996. graf
Article
in English
| LILACS
| ID: lil-161677
ABSTRACT
Angiotensin II (ANG II) administered centrally produces drinking by acting on subtype 1 ANG II (AT1) receptors. Carbachol, a cholinergic receptor agonist, also induces drinking behavior by a central action. In the present study we determined whether the response to carbachol also involves AT1 receptors. Male Holtzman rats (250-300 g) with stainless steel cannula implanted into the lateral ventricle (LV) were used. Water intake after injection of 0. 15 M NaCl (1.0 microL) into the LV was 0.2 +/- 0.01 ml/h (N = 8). The AT1 receptor antagonist DUP-753 (50 nmol/microL) injected into the LV reduced water intake induced by ANG H (10 nmol/microL) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/microL) from 9.8 +/- 1.4 ml/h to 3.7 +/- 0.8 ml/h (N = 8). These results suggest that AT1 receptors play a role in the drinking behavior observed after central cholinergic stimulation in rats.
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Index:
LILACS (Americas)
Main subject:
Tetrazoles
/
Biphenyl Compounds
/
Angiotensin II
/
Carbachol
/
Receptors, Angiotensin
/
Drinking
/
Imidazoles
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
/
Congress and conference
/
Project document
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