Substance P does not modify mononuclear cell migration into Ehrlich tumor mass
Braz. j. med. biol. res
;
29(3): 359-62, Mar. 1996. ilus, tab
Article
in English
| LILACS
| ID: lil-163844
RESUMO
In the present study, seven adult male mice were inoculated with Ehrlich tumor into the footpad after local substance P release was blocked by neurectomy of the sciatic and saphenous nerves. The contralateral footpad was also inoculated but sham-operated, and used as control. This procedure did not modify the percent of CD4+ (about 1-2 per cent), CD8+ (about 1-3 per cent), macrophages (about 21-22 per cent), lymphocyte B (about 0-1 per cent) and NK (about 1-2 per cent) mononuclear cells present among tumor cells. These data suggest that chemotactic activity of substance P may not be relevant in this situation because the lack of this neurotransmitter (checked by immunohistochemistry) secondary to neurectomy did not change the cell migration profile into tumor mass.
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Index:
LILACS (Americas)
Main subject:
B-Lymphocytes
/
Carcinoma, Ehrlich Tumor
/
T-Lymphocytes
/
Substance P
/
Macrophages
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
/
Congress and conference
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